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Sodium channel inhibitors alter the progress of tangle development in a mouse model of dementia

2024-08-27

Abstract excerpt

<h4>ABSTRACT</h4> Sodium channel inhibitors have been reported to protect against a range of neuroinflammatory and neurodegenerative diseases. Here the effect of chronic administration of two Na + channel inhibitors with different mechanisms of action, phenytoin and GS967 are tested in mouse models of different stages of Alzheimer’s disease. Subtle changes in the distribution of plaque sizes were observed in Ap...

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Literature Corpus work
ef2de4d8-7e6e-52a5-a070-ece80b60e9ca
DOI
10.1101/2024.08.26.609302
Open publication

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Sodium channel inhibitors alter the progress of tangle development in a mouse model of dementiaDOI 10.1101/2024.08.26.609302
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