Article
Microdose Lithium NP03 Diminishes Pre-Plaque Oxidative Damage and Neuroinflammation in a Rat Model of Alzheimer's-like Amyloidosis.
Current Alzheimer research - 1 Jan 2018
Wilson Edward N, Do Carmo Sonia, Iulita M Florencia, Hall Hélène, Austin Grant L, Jia Dan T, Malcolm Janice C, Foret Morgan K, Marks Adam R, Butterfield D Allan, Cuello A Claudio
Abstract excerpt
BACKGROUND: Microdose lithium is protective against Alzheimer's disease (AD), although the precise mechanisms through which its protective effects are conferred remain unclear. OBJECTIVE: To further examine the effects during the earliest stages of Aβ pathology, we evaluated whether NP03, a microdose lithium formulation, modulates Aβ-mediated oxidative damage and neuroinflammation when applied to a rat transgenic...
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