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Article

Lithium treatment arrests the development of neurofibrillary tangles in mutant tau transgenic mice with advanced neurofibrillary pathology.

Journal of Alzheimer's disease : JAD - 1 Jan 2010

Leroy Karelle, Ando Kunie, Héraud Céline, Yilmaz Zehra, Authelet Michèle, Boeynaems Jean-Marie, Buée Luc, De Decker Robert, Brion Jean-Pierre

Abstract excerpt

Neurofibrillary tangles (NFTs) made of phosphorylated tau proteins are a key lesion of Alzheimer's disease and other neurodegenerative diseases, and previous studies have indicated that lithium can decrease tau phosphorylation in tau transgenic models. In this study, we have reassessed the effectiveness of treatment per os with lithium on the prevention, the arrest, or the reversal of NFT development in a tau...

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Identifiers

PMID: 20110614
DOI: 10.3233/JAD-2010-1276

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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