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Article

Rationale for an adjunctive therapy with fenofibrate in pharmacoresistant nocturnal frontal lobe epilepsy.

Epilepsia - 1 Oct 2017

Puligheddu Monica, Melis Miriam, Pillolla Giuliano, Milioli Giulia, Parrino Liborio, Terzano Giovanni Mario, Aroni Sonia, Sagheddu Claudia, Marrosu Francesco, Pistis Marco, Muntoni Anna Lisa

Abstract excerpt

OBJECTIVE: Nocturnal frontal lobe epilepsy (NFLE) is an idiopathic partial epilepsy with a family history in about 25% of cases, with autosomal dominant inheritance (autosomal dominant NFLE [ADNFLE]). Traditional antiepileptic drugs are effective in about 55% of patients, whereas the rest remains refractory. One of the key pathogenetic mechanisms is a gain of function of neuronal nicotinic acetylcholine receptors...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28766701
DOI: 10.1111/epi.13863

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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