Article
The role of EMT and MET in cancer dissemination.
Connective tissue research - 1 Jan 2015
Banyard Jacqueline, Bielenberg Diane R
Abstract excerpt
Metastatic cancer cells are lethal. Understanding the molecular mechanisms that bolster the conversion from benign to malignant progression is key for treating these heterogeneous and resistant neoplasms. The epithelial-mesenchymal transition (EMT) is a conserved cellular program that alters cell shape, adhesion and movement. The shift to a more mesenchymal-like phenotype can promote tumor cell intravasation of...
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