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Article

Cell fusion as a driver of metastasis: re-evaluating an old hypothesis in the age of cancer heterogeneity

4 Feb 2025

Abstract excerpt

Numerous studies have investigated the molecular mechanisms and signalling pathways underlying cancer metastasis, as there is still no effective treatment for this terminal stage of the disease. However, the exact processes that enable primary cancer cells to acquire a metastatic phenotype remain unclear. Increasing attention has been focused on the fusion of cancer cells with myeloid cells, a phenomenon that may...

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PMID: 39967663
DOI: 10.3389/fimmu.2025.1524781

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