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Article

Human pancreatic cancer cell exosomes, but not human normal cell exosomes, act as an initiator in cell transformation

27 May 2019

Abstract excerpt

Cancer evolves through a multistep process that occurs by the temporal accumulation of genetic mutations. Tumor-derived exosomes are emerging contributors to tumorigenesis. To understand how exosomes might contribute to cell transformation, we utilized the classic two-step NIH/3T3 cell transformation assay and observed that exosomes isolated from pancreatic cancer cells, but not normal human cells, can initiate...

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PMID: 31134894
DOI: 10.7554/elife.40226

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