Article

PD-L1 expression is mediated by microRNA processing, Wnt/β-catenin signaling, and chemotherapy in Wilms tumor

2024-12-03

Abstract excerpt

<h4>ABSTRACT</h4> Inhibition of immune checkpoint proteins is effective in adult cancers but has shown limited efficacy in pediatric cancers. While factors regulating expression of immune checkpoint proteins such as PD-L1 are well-documented in adult cancers, their regulation is poorly understood in pediatric cancers. Here, we show that PD-L1 is upregulated in distinct subsets of Wilms tumor, the most common pedi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: eefa8207-52c6-5e75-b4e0-272b2b3932f6
DOI: 10.1101/2024.11.29.626084

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

PD-L1 expression is mediated by microRNA processing, Wnt/β-catenin signaling, and chemotherapy in Wilms tumorDOI 10.1101/2024.11.29.626084Read

PD-L1 Expression is Mediated by microRNA Processing, Wnt/β-Catenin Signaling, and Chemotherapy in Wilms Tumor.Semantic proximity Read

Wilms tumor mutational subclasses converge to drive<i>CCND2</i>overexpressionSemantic proximity Read

The Immune landscape of pediatric solid tumorsSemantic proximity Read

Immune checkpoint markers and tumour mutation burden in Wilms tumour: a study of 59 cases.Semantic proximity Read

DROSHA Regulates Mesenchymal Gene Expression in Wilms Tumor.Semantic proximity Read

Integrative Transcriptomic Profiling Reveals Novel Biomarkers in Wilms TumorSemantic proximity Read

Cyclin B1 is a novel prognostic biomarker and promotes proliferation, migration and invasion in Wilms TumourSemantic proximity Read

Mutations in the SIX1/2 pathway and the DROSHA/DGCR8 miRNA microprocessor complex underlie high-risk blastemal type Wilms tumors.Semantic proximity Read

Multi-Omics and Machine Learning Integration of Diverse Cell Death Pathways Optimize Risk Stratification and Inform Drug Therapy in Wilms TumorSemantic proximity Read

mTORC-Driven Immunogenomic Reprogramming Shapes Prognosis and Therapeutic Vulnerabilities in Unfavorable Histology Wilms TumorSemantic proximity Read

The DGCR8 E518K mutation found in Wilms tumors leads to a partial miRNA processing defect that alters gene expression patterns and biological processes.Semantic proximity Read

Dysregulation of the Hippo pathway enhances PD-L2 transcription to promote cancer immune evasionSemantic proximity Read