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Article

PD-L1 Expression is Mediated by microRNA Processing, Wnt/β-Catenin Signaling, and Chemotherapy in Wilms Tumor.

Pediatric blood & cancer - 1 Sept 2025

Tiburcio Patricia D B, Desai Kavita, Warne Austin, Nabbi Arash, Zhou Serena, Reiff Sean D, Campbell Matthew E, Amatruda James F, Chen Kenneth S

Abstract excerpt

BACKGROUND: Inhibition of immune checkpoint proteins is effective in adult cancers but has shown limited efficacy in pediatric cancers. While factors regulating expression of immune checkpoint proteins such as PD-L1 are well documented in adult cancers, their regulation is poorly understood in pediatric cancers. METHODS: We analyzed Wilms tumor specimens with reverse-phase protein arrays. We validated...

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Share to B7-H1 Antigen
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

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Source

Open in PubMed Open full text

Identifiers

PMID: 40512079
DOI: 10.1002/pbc.31852
PMCID: PMC13231507

Genes

DROSHA
CTNNB1
DICER1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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