Article

mTORC-Driven Immunogenomic Reprogramming Shapes Prognosis and Therapeutic Vulnerabilities in Unfavorable Histology Wilms Tumor

2026-01-27

Abstract excerpt

<title>Abstract</title> <p> Unfavorable Histology Wilms Tumor (UFH-WT) is a high-risk pediatric renal malignancy with poor prognosis, and the mTORC pathway's role in its heterogeneity, immune remodeling, and therapeutic vulnerability remains unclear, restricting its clinical application as a prognostic biomarker and therapeutic target. Integrative multiomics analysis of transcriptomic, genomic, and clinical data...

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Literature Corpus work: 289db902-38e7-5fc0-b843-49f5a555a9c3
DOI: 10.21203/rs.3.rs-8396890/v1

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