Article

In vitro evaluation of cytotoxicity caused by carbamazepine and its metabolites in association to carbamazepine-induced hypersensitivity reactions

2014-01-01

Abstract excerpt

Carbamazepine (CBZ), an anticonvulsant and mood-stabilising drug, is known to cause delayed type hypersensitivity reactions. These reactions occur only in a minority of patients treated with the drug, but often result in severe clinical outcomes. Although an association between CBZ-induced hypersensitivity reactions and HLA alleles has been demonstrated, the underlying mechanism(s) of toxicity are poorly understoo...

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Literature Corpus work: b5ae98da-340d-5420-97a3-cc59077fdf9a
DOI: 10.17638/02025988

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