Article

<i>E-cadherin</i>Gene Promoter Hyper-methylation in Blood Samples from Breast Cancer Cases

2021-04-06

Abstract excerpt

In carcinomas, dissemination of cancer cells via blood or lymph circulation constitutes an early event. E-cadherin is a transmembrane calcium dependent adhesion protein. Cellular de-differentiation and plasticity, underlying metastasis, is attributed to the loss of function of E-cadherin ( cdh1 ) gene. The loss of gene expression may arise from promoter hypermethylation, which has been reported in multiple cancers...

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Literature Corpus work: eedc9a51-918d-5fec-a258-6e911da00c0d
DOI: 10.1101/2021.03.30.21254647

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