Article

Lysine 117 on ataxin-3 modulates toxicity in <i>Drosophila</i> models of Spinocerebellar Ataxia Type 3

2023-06-01

Abstract excerpt

<h4>ABSTRACT</h4> Ataxin-3 (Atxn3) is a deubiquitinase with a polyglutamine (polyQ) repeat tract whose abnormal expansion causes the neurodegenerative disease, Spinocerebellar Ataxia Type 3 (SCA3; also known as Machado-Joseph Disease). The ubiquitin chain cleavage properties of Atxn3 are enhanced when it is ubiquitinated at lysine (K) at position 117. K117-ubiqutinated Atxn3 cleaves poly-ubiquitin more rapidly in...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: eed737e8-722f-5efb-993e-d855f32b8e9c
DOI: 10.1101/2023.05.30.542896

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Lysine 117 on ataxin-3 modulates toxicity in <i>Drosophila</i> models of Spinocerebellar Ataxia Type 3DOI 10.1101/2023.05.30.542896Read

Progressive degeneration in a new <i>Drosophila</i> model of Spinocerebellar Ataxia type 7Semantic proximity Read

Regional and age-dependent changes in ubiquitination in cellular and mouse models of Spinocerebellar ataxia type 3Semantic proximity Read

Ubiquitination regulates the neuroprotective function of the deubiquitinase ataxin-3 in vivo.Semantic proximity Read

Progressive degeneration in a new Drosophila model of Spinocerebellar Ataxia type 7Semantic proximity Read

Blood and cerebellar abundance of <i>ATXN3</i> splice variants in spinocerebellar ataxia type 3/Machado-Joseph diseaseSemantic proximity Read

Phenotypic defects from the expression of wild-type and pathogenic TATA-Binding Proteins in new <i>Drosophila</i> models of Spinocerebellar Ataxia Type 17Semantic proximity Read

Large-Scale Screen for Modifiers of Ataxin-3-Derived Polyglutamine-Induced Toxicity in DrosophilaSemantic proximity Read

Druggable genome screen identifies new regulators of the abundance and toxicity of ATXN3, the Spinocerebellar Ataxia Type 3 disease proteinSemantic proximity Read

A conditional pan-neuronal Drosophila model of spinocerebellar ataxia 7 with a reversible adult phenotype suitable for identifying modifier genes.Semantic proximity Read

The Machado–Joseph Disease Deubiquitinase Ataxin-3 Regulates the Stability and Apoptotic Function of p53Semantic proximity Read

Mutant Ataxin-3-Containing Aggregates (MATAGGs) in Spinocerebellar Ataxia Type 3: Dynamics of the Disorder.Semantic proximity Read

Ubiquitin-mediated sequestration of normal cellular proteins into polyglutamine aggregates.Semantic proximity Read