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Phenotypic defects from the expression of wild-type and pathogenic TATA-Binding Proteins in new <i>Drosophila</i> models of Spinocerebellar Ataxia Type 17

2023-05-24

Abstract excerpt

<h4>ABSTRACT</h4> Spinocerebellar Ataxia Type 17 (SCA17) is the most recently identified member of the polyglutamine (polyQ) family of disorders, resulting from abnormal CAG/CAA expansion of TATA box binding protein (TBP), an initiation factor essential for of all eukaryotic transcription. A largely autosomal dominant inherited disease, SCA17 is unique in both its heterogeneous clinical presentation and low incid...

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Literature Corpus work
7bf1066c-23a4-58f4-a4a0-842561446ef2
DOI
10.1101/2023.05.22.541820
Open publication

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Phenotypic defects from the expression of wild-type and pathogenic TATA-Binding Proteins in new <i>Drosophila</i> models of Spinocerebellar Ataxia Type 17DOI 10.1101/2023.05.22.541820
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