Article

AD-HIES patients retain preTh17-cells that produce IL10 with opportunistic pathogens and induce IgE

2024-08-04

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Autosomal Dominant-Hyper-IgE Syndrome (AD-HIES) is caused by dominant-negative (DN) STAT3 mutations and characterized by high IgE levels, a lack of Th17-cells and recurrent infections with extracellular pathogens. We previously identified an enigmatic population of IL-10 producing CCR6 + B-helper T-cells and investigated here their relationship to Th17-cells and STAT3 signa...

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Literature Corpus work: eea89ef2-1c64-5c49-a93e-8f58aee954ef
DOI: 10.1101/2024.08.01.606136

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