Article
Dedicator of cytokinesis 8 regulates signal transducer and activator of transcription 3 activation and promotes TH17 cell differentiation.
The Journal of allergy and clinical immunology - 1 Nov 2016
Keles Sevgi, Charbonnier Louis Marie, Kabaleeswaran Venkataraman, Reisli Ismail, Genel Ferah, Gulez Nesrin, Al-Herz Waleed, Ramesh Narayanaswamy, Perez-Atayde Antonio, Karaca Neslihan E, Kutukculer Necil, Wu Hao, Geha Raif S, Chatila Talal A
Abstract excerpt
BACKGROUND: The autosomal recessive hyper-IgE syndrome (HIES) caused by dedicator of cytokinesis 8 (DOCK8) deficiency shares clinical features with autosomal dominant HIES because of signal transducer and activator of transcription 3 (STAT3) mutations, including recurrent infections and mucocutaneous candidiasis, which are suggestive of TH17 cell dysfunction. The mechanisms underlying this phenotypic overlap are...
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