Article

AD-HIES patients retain preTh17-cells that produce IL10 with opportunistic pathogens and induce IgE

2025-06-24

Abstract excerpt

11pt, fleqn, a4paper, ]LegrandOrangeBook <h4>Background: </h4> Autosomal Dominant-Hyper-IgE Syndrome (AD-HIES) is caused by dominant-negative (DN) STAT3 mutations and characterized by high IgE levels, a lack of Th17-cells and recurrent infections with extracellular pathogens. We previously identified an enigmatic population of IL-10 producing CCR6 + B-helper T-cells and investigated here their relationship to Th...

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Literature Corpus work: 05647420-d58b-5094-bc32-ec6d73146d43
DOI: 10.22541/au.175074317.76109643/v1

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