Article
Key findings to expedite the diagnosis of hyper-IgE syndromes in infants and young children.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology - 1 Mar 2016
Hagl Beate, Heinz Valerie, Schlesinger Anne, Spielberger Benedikt D, Sawalle-Belohradsky Julie, Senn-Rauh Monika, Magg Thomas, Boos Annette C, Hönig Manfred, Schwarz Klaus, Dückers Gregor, von Bernuth Horst, Pache Christoph, Karitnig-Weiss Cäcilia, Belohradsky Bernd H, Frank Josef, Niehues Tim, Wahn Volker, Albert Michael H, Wollenberg Andreas, Jansson Annette F, Renner Ellen D
Abstract excerpt
BACKGROUND: Hyper-IgE syndromes (HIES) are primary immunodeficiency disorders characterized by elevated serum IgE, eczema, and recurrent infections. Despite the availability of confirmatory molecular diagnosis of several distinct HIES entities, the differentiation of HIES particularly from severe forms of atopic dermatitis remains a challenge. The two most common forms of HIES are caused by mutations in the genes...
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