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Article

WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrate.

The Biochemical journal - 15 Feb 2004

Vitari Alberto C, Deak Maria, Collins Barry J, Morrice Nick, Prescott Alan R, Phelan Anne, Humphreys Sian, Alessi Dario R

Abstract excerpt

Recent evidence indicates that mutations in the gene encoding the WNK1 [with no K (lysine) protein kinase-1] results in an inherited hypertension syndrome called pseudohypoaldosteronism type II. The mechanisms by which WNK1 is regulated or the substrates it phosphorylates are currently unknown. W...

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Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Ribosomal Protein S6 Kinases, 90-kDa

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Source

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Identifiers

PMID: 14611643
DOI: 10.1042/BJ20031692
PMCID: PMC1223938

Genes

WNK1
IGF1
PDK1
SGK1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14611643-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrate.PMID 14611643Read ↗

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