Article

The translational role of SOS1 in colorectal cancer

2022-10-14

Abstract excerpt

<h4>Background</h4> It has been challenging to develop agents directly targeting KRAS driver mutations in colorectal cancer (CRC). Recent efforts have focused on developing inhibitors targeting SOS1 as an attractive approach for KRAS -mutant cancers. Here, we aimed to study the translational role of SOS1 in CRC using patient-derived organoids (PDOs). <h4>Method</h4> In this study, we used CRC PDOs as preclini...

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Literature Corpus work: ee86f80d-3260-59e6-92de-a8d188b87f2f
DOI: 10.1101/2022.10.14.512156

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