Article
Translational relevance of SOS1 targeting for KRAS-mutant colorectal cancer.
Molecular carcinogenesis - 1 Jul 2023
Alem Diego, Yang Xinrui, Beato Francisca, Sarcar Bhaswati, Tassielli Alexandra F, Dai Ruifan, Hogenson Tara L, Park Margaret A, Jiang Kun, Cai Jianfeng, Yuan Yu, Fernandez-Zapico Martin E, Tan Aik Choon, Fleming Jason B, Xie Hao
Abstract excerpt
It has been challenging to target mutant KRAS (mKRAS) in colorectal cancer (CRC) and other malignancies. Recent efforts have focused on developing inhibitors blocking molecules essential for KRAS activity. In this regard, SOS1 inhibition has arisen as an attractive approach for mKRAS CRC given its essential role as a guanine nucleotide exchange factor for this GTPase. Here, we demonstrated the translational value...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.