SOS1: tracking the evolving path from promising to actionable therapeutic target in RAS-dependent cancers.

Abstract excerpt

SOS1 is a crucial guanine nucleotide exchange factor (GEF) that plays a key role in the activation of eukaryotic RAS GTPases, serving as a critical node in the highly conserved RAS/MAPK signaling pathway. Dysregulation of the RAS-MAPK pathway, which is frequently driven by oncogenic RAS mutations, is implicated in approximately 30% of all human cancers, making it one of the most prevalent oncogenic drivers. As a...

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