Article

Ciliary ARL13B is essential for body weight regulation in mice

2023-08-04

Abstract excerpt

Primary cilia are sensory cellular appendages that regulate diverse developmental and homeostatic processes, including energy homeostasis. In animal models and humans, their dysfunction can lead to hyperphagia and obesity. ARL13B is a regulatory GTPase enriched in cilia. We engineered an Arl13b mouse allele, Arl13b V358A , that disrupts ARL13B from localizing to primary cilia. Homozygous Arl13b V358A/V358A mi...

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Literature Corpus work: ee814176-89ce-547c-be17-f3d33d4781e0
DOI: 10.1101/2023.08.02.551695

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