Article
A truncating mutation of Alms1 reduces the number of hypothalamic neuronal cilia in obese mice.
Developmental neurobiology - 1 Jan 2013
Heydet Déborah, Chen Lesley X, Larter Claire Z, Inglis Chrystal, Silverman Michael A, Farrell Geoffrey C, Leroux Michel R
Abstract excerpt
Primary cilia are ubiquitous cellular antennae whose dysfunction collectively causes various disorders, including vision and hearing impairment, as well as renal, skeletal, and central nervous system anomalies. One ciliopathy, Alström syndrome, is closely related to Bardet-Biedl syndrome (BBS), sharing amongst other phenotypic features morbid obesity. As the cellular and molecular links between weight regulation...
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