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Article

Inorganic Cadmium- and Arsenite-Induced Malignant Transformation of Human Bladder Urothelial Cells

21 Jan 2004

Abstract excerpt

Arsenic and cadmium (Cd(+2)) are human carcinogens, and epidemiological studies have implicated both pollutants in the development of urinary bladder cancer. Despite this epidemiological base, it is unknown if either Cd(+2) or arsenite (As(+3)) can directly cause the malignant transformation of human urothelial cells. The goal of this study was to determine if Cd(+2) and/or As(+3) are able to cause the malignant...

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PMID: 14976345
DOI: 10.1093/toxsci/kfh086

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