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Article

PLSCR1 promotes apoptosis and clearance of retinal ganglion cells in glaucoma pathogenesis

21 Jun 2022

Abstract excerpt

Glaucoma is the leading cause of irreversible blindness worldwide. In the pathogenesis of glaucoma, activated microglia can lead to retinal ganglion cells (RGCs) apoptosis and death, however, the molecular mechanisms remain largely unknown. We demonstrate that phospholipid scramblase 1 (PLSCR1) is a key regulator promoting RGCs apoptosis and their clearance by microglia. As evidenced in retinal progenitor cells...

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Share to Glaucoma and retinal disorders
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PMID: 37397520
DOI: 10.1016/j.gendis.2022.05.036

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