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Article

NLRP12 collaborates with NLRP3 and NLRC4 to promote pyroptosis inducing ganglion cell death of acute glaucoma

15 Apr 2020

Abstract excerpt

BACKGROUND: Acute glaucoma, characterized by a sudden elevation in intraocular pressure (IOP) and retinal ganglion cells (RGCs) death, is a major cause of irreversible blindness worldwide that lacks approved effective therapies, validated treatment targets and clear molecular mechanisms. We sought to explore the potential molecular mechanisms underlying the causal link between high IOP and glaucomatous RGCs...

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Share to Glaucoma and retinal disorders
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Share to Ocular Diseases and Behçet’s Syndrome

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PMID: 32295623
DOI: 10.1186/s13024-020-00372-w

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