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Changes in mitochondrial distribution occur at the axon initial segment in association with neurodegeneration in <i>Drosophila</i>

2024-02-14

Abstract excerpt

<h4>ABSTRACT</h4> Changes in mitochondrial distribution are a feature of numerous age-related neurodegenerative diseases. In Drosophila , reducing the activity of Cdk5 causes a neurodegenerative phenotype and is known to affect several mitochondrial properties. Therefore, we investigated whether alterations of mitochondrial distribution are involved in Cdk5-associated neurodegeneration. We find that reducing Cdk...

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Literature Corpus work
ee5428ba-78fc-52ef-81ce-15909877db54
DOI
10.1101/2024.02.14.580288
Open publication

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