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Article

Absence of the Cdk5 activator p35 causes adult-onset neurodegeneration in the central brain of Drosophila.

Disease models & mechanisms - 1 Mar 2012

Trunova Svetlana, Giniger Edward

Abstract excerpt

Altered function of Cdk5 kinase is associated with many forms of neurodegenerative disease in humans. We show here that inactivating the Drosophila Cdk5 ortholog, by mutation of its activating subunit, p35, causes adult-onset neurodegeneration in the fly. In the mutants, a vacuolar neuropathology is observed in a specific structure of the central brain, the 'mushroom body', which is the seat of olfactory learning...

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Identifiers

PMID: 22228754
DOI: 10.1242/dmm.008847
PMCID: PMC3291642

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