Effects of Familial Alzheimer’s Disease Mutations on the Folding Free Energy and Dipole-Dipole Interactions of the Amyloid <i>β</i> -Peptide

Abstract excerpt

Familial Alzheimer’s disease (FAD) mutations of the amyloid β -peptide (A β ) are known to lead to early onset and more aggressive Alzheimer’s disease. FAD mutations such as “Iowa” (D23N), “Arctic” (E22G), “Italian” (E22K), and “Dutch” (E22Q) have been shown to accelerate A β aggregation relative to the wild-type (WT). The mechanism by which these mutations facilitate increased aggregation is unknown, but each...

Topics

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• Alzheimer Disease
• Amyloid beta-Peptides
• Molecular Dynamics Simulation
• Mutation
• Peptide Fragments
• Protein Folding
• Protein Multimerization
• Solvents

Identifiers and source

Literature Corpus work

ee2d12f0-ca31-53c1-bc18-495379997ebf

DOI

10.1101/2022.05.19.492750