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Article

Structural heterogeneity in familial Alzheimer's disease mutants of amyloid-beta peptides.

Molecular bioSystems - 1 May 2013

Chong Song-Ho, Yim Janghyun, Ham Sihyun

Abstract excerpt

Alzheimer's disease is a neurodegenerative disorder characterized by progressive deposition of amyloid-beta (Aβ) peptides in brain parenchyma and cerebral blood vessels. Several pathogenic familial mutations of Aβ peptides have been identified that exhibit enhanced neurotoxicity and aggregative ability. However, knowledge of the structural characteristics of those Aβ mutants is still limited. Here, we report...

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Alzheimer Disease
Amyloid beta-Peptides
Circular Dichroism
Genetic Heterogeneity
Magnetic Resonance Spectroscopy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Dynamics Simulation

Peptide Fragments

Protein Structure, Secondary

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PMID: 23358498
DOI: 10.1039/c2mb25457c

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