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Gene therapy pipelines for osteoarthritis: current innovations, operational challenges, and future directions

4 Jul 2025

Abstract excerpt

Osteoarthritis (OA) is a multifactorial joint disease characterized by progressive cartilage degradation, synovial inflammation, and subchondral bone remodeling. Despite its significant global health burden, there are currently no disease-modifying pharmacological therapies for OA. Gene therapy, leveraging viral and non-viral vectors to deliver therapeutic transgenes into the joint environment, shows significant...

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PMID: 40611652
DOI: 10.1080/03008207.2025.2520319

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