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Three-Dimensional Spheroid Primary Human Hepatocytes in Monoculture and Coculture with Nonparenchymal Cells

13 Aug 2018

Abstract excerpt

Recent advances in the development of various culture platforms are promising for achieving more physiologically relevant in vitro hepatic models using primary human hepatocytes (PHHs). Previous studies have shown the value of PHHs three-dimensional (3D) spheroid models, cultured in low cell number (1330–2000 cells/3D spheroid), to study long-term liver function as well as pharmacological drug effects and...

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PMID: 30101670
DOI: 10.1089/ten.tec.2018.0134

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