Article

Development of nanobodies as theranostic agents against CMY-2-like class C β-lactamases

2022-07-03

Abstract excerpt

<h4>ABSTRACT</h4> Soluble single-domain fragments derived from the unique variable region of camelid heavy-chain antibodies (VHHs) against enzymes may behave as potent inhibitors. The immunization of alpacas with the CMY-2 β-lactamase led to the isolation of three VHHs that specifically recognized and inhibited CMY-2. The structure of the complex VHH cAb CMY-2 (254)/CMY-2 was determined by X-ray crystallography....

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Literature Corpus work: edf18b26-61d4-5e7b-a865-eb7848199b86
DOI: 10.1101/2022.07.01.498528

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