Article

Single-Domain Antibodies as Potent Inhibitors of Clinically Relevant β-Lactamases in Multidrug-Resistant Bacteria

2025-12-03

Abstract excerpt

Antimicrobial resistance (AMR) represents a critical threat to global health, largely driven by the dissemination of β-lactamases that inactivate frontline antibiotics. Among the most problematic are BlaMab-2 from Mycobacterium abscessus , KPC-2 and OXA-48 from Klebsiella pneumoniae , and VIM-2 from Pseudomonas aeruginosa , which together confer broad resistance to β-lactams and carbapenems. Current β-lactamase...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 218bc4a8-3b64-5466-bf4c-2a8aad9c69a3
DOI: 10.64898/2025.12.03.691997

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-Domain Antibodies as Potent Inhibitors of Clinically Relevant β-Lactamases in Multidrug-Resistant BacteriaDOI 10.64898/2025.12.03.691997Read

Tackling the Antibiotic Resistance Caused by Class A β-Lactamases through the Use of β-Lactamase Inhibitory ProteinSemantic proximity Read

Structural perspectives on clinical β-lactamase inhibitors: From mechanism to resistance.Semantic proximity Read

Diversity and Proliferation of Metallo-β-Lactamases: a Clarion Call for Clinically Effective Metallo-β-Lactamase InhibitorsSemantic proximity Read

Recent advances in the development of β-lactamase inhibitorsSemantic proximity Read

High-throughput single-cell analysis reveals fully human Omp38-specific monoclonal antibodies against Acinetobacter baumanniiSemantic proximity Read

Old and New Beta-Lactamase Inhibitors: Molecular Structure, Mechanism of Action, and Clinical UseSemantic proximity Read

Enzyme Inhibitors: The Best Strategy to Tackle Superbug NDM-1 and Its Variants.Semantic proximity Read

Development of nanobodies as theranostic agents against CMY-2-like class C β-lactamasesSemantic proximity Read

Progress Toward Inhibitors of Metallo-β-LactamasesSemantic proximity Read

4-Amino-2-Sulfanylbenzoic Acid as a Potent Subclass B3 Metallo-β-Lactamase-Specific Inhibitor Applicable for Distinguishing Metallo-β-Lactamase SubclassesSemantic proximity Read

Virtual screening identifies broad-spectrum β-lactamase inhibitors with activity on clinically relevant serine- and metallo-carbapenemasesSemantic proximity Read

β-Lactamases and β-Lactamase Inhibitors in the 21st CenturySemantic proximity Read