Air-pollutant chemicals and oxidized lipids exhibit genome-wide synergistic effects on endothelial cells

Abstract excerpt

BACKGROUND: Ambient air pollution is associated with increased cardiovascular morbidity and mortality. We have found that exposure to ambient ultrafine particulate matter, highly enriched in redox cycling organic chemicals, promotes atherosclerosis in mice. We hypothesize that these pro-oxidative chemicals could synergize with oxidized lipid components generated in low-density lipoprotein particles to enhance...

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