Article

From Mutation to Metabolism: Environmental and Dietary Toxins as Upstream Drivers of Mitochondrial Dysfunction and Chronic Disease

2025-09-22

Abstract excerpt

Environmental and dietary exposures contribute to the modern burden of cancer, atherosclerotic cardiovascular disease (ASCVD), and type 2 diabetes mellitus (T2DM). While mutagenesis remains central to carcinogenesis, many exposures impair mitochondrial function—disrupting electron transport, depolarizing membranes, damaging mitochondrial DNA, and amplifying reactive oxygen species. These mitochondrial injuries con...

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Literature Corpus work: 82f0f46d-8e25-5cea-ac03-7e9ad562c7de
DOI: 10.20944/preprints202509.1767.v1

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