Article
Mutated MITF-E87R in Melanoma Enhances Tumor Progression via S100A4.
The Journal of investigative dermatology - 1 Oct 2018
Nordlinger Alice, Dror Shani, Elkahloun Abdel, Del Rio Justine, Stubbs Elisa, Golan Tami, Malcov Hagar, Pricket Todd D, Cronin Julia C, Parikh Shivang, Labes Sapir, Thomas Laetitia, Yankovitz Gal, Tabach Yuval, Levy Carmit, Samuels Yardena, Khaled Mehdi
Abstract excerpt
Melanoma, a melanocyte origin neoplasm, is the most lethal type of skin cancer, and incidence is increasing. Several familial and somatic mutations have been identified in the gene encoding the melanocyte lineage master regulator, MITF; however, the neoplastic mechanisms of these mutant MITF variants are mostly unknown. Here, by performing unbiased analysis of the transcriptomes in cells expressing mutant MITF,...
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