Article

LRRK2 Kinase Activity Regulates Parkinson’s Disease-Relevant Lipids at the Lysosome

2022-12-19

Abstract excerpt

Lysosomal dysfunction is a hallmark of Parkinson’s disease (PD), and variants in several PD-associated genes, including LRRK2 , perturb lysosomal homeostasis. Based on this, LRRK2 kinase inhibition is being explored as a therapeutic approach for the treatment of PD. LRRK2 inhibitors reduce levels of BMP, an endolysosomal lipid involved in glycosphingolipid (GSL) catabolism, in urine from preclinical models and cl...

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Literature Corpus work: ed958101-50eb-5235-ba51-5739f8df1bc3
DOI: 10.1101/2022.12.19.521070

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LRRK2 Kinase Activity Regulates Parkinson’s Disease-Relevant Lipids at the LysosomeDOI 10.1101/2022.12.19.521070Read

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