Article

Extracellular vesicle-mediated release of bis(monoacylglycerol)phosphate is regulated by LRRK2 and Glucocerebrosidase activity

2023-07-13

Abstract excerpt

<h4>ABSTRACT</h4> The endolysosomal phospholipid, bis(monoacylglycerol)phosphate (BMP), is aberrantly elevated in the urine of Parkinson’s patients with mutations in genes encoding leucine-rich repeat kinase 2 (LRRK2) and glucocerebrosidase (GCase). Because BMP resides on and regulates the biogenesis of endolysosomal intralumenal membranes that become extracellular vesicles (EVs) upon release, we hypothesized tha...

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Literature Corpus work: b8126efa-e41b-5eb2-873a-3134676ca0fc
DOI: 10.1101/2023.07.12.548710

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