Article

Translational lipidomics reveals BMP and its precursor LPG as biomarkers for CLN5 Batten disease

2026-03-21

Abstract excerpt

CLN5 Batten disease, caused by biallelic mutations in CLN5 , is a rare, early-onset neurodegenerative lysosomal storage disorder that has no cure and lacks validated biomarkers, hindering accurate diagnosis and assessment of therapeutic response. We recently identified CLN5 as the synthase of bis(monoacylglycero)phosphate (BMP), an endolysosomal phospholipid crucial for lysosome function and lipid catabolism. Thi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: dc47d79d-c8e3-5418-98cb-9ad13b83343d
DOI: 10.64898/2026.03.19.712969

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Translational lipidomics reveals BMP and its precursor LPG as biomarkers for CLN5 Batten diseaseDOI 10.64898/2026.03.19.712969Read

Robust analytical methods for bis(monoacylglycero)phosphate profiling in health and diseaseSemantic proximity Read

Stereospecific GPG acylation by CLN8 drives BMP biosynthesis and its loss leads to Batten diseaseSemantic proximity Read

The endolysosomal phospholipid bis(monoacylglycero)phosphate is synthesized via intra- and extracellular pathwaysSemantic proximity Read

CLN5 deficiency impairs glucose uptake in Batten diseaseSemantic proximity Read

Longitudinal Deep Multi-Omics Profiling in a <i> CLN3 <sup>Δex7/8</sup> </i> Minipig Model Reveals Novel Biomarker Signatures for Batten DiseaseSemantic proximity Read

Characterisation of early changes in ovine CLN5 and CLN6 Batten disease neural cultures for the rapid screening of therapeutics.Semantic proximity Read

A lysosomal enigma CLN5 and its significance in understanding neuronal ceroid lipofuscinosis.Semantic proximity Read

CLN5 deficiency impairs glucose uptake and uncovers PHGDH as a potential biomarker in Batten diseaseSemantic proximity Read

PLA2G15 is a Lysosomal BMP Hydrolase and its Targeting Ameliorates Lysosomal DiseaseSemantic proximity Read

Molecular insights into ATP synthase c-ring accumulation in BMP-deficient lysosomes in Batten diseaseSemantic proximity Read

Extracellular vesicle-mediated release of bis(monoacylglycerol)phosphate is regulated by LRRK2 and Glucocerebrosidase activitySemantic proximity Read

LRRK2 Kinase Activity Regulates Parkinson’s Disease-Relevant Lipids at the LysosomeSemantic proximity Read