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C24 sphingolipids play a surprising and central role in governing cholesterol and lateral organization of the live cell plasma membrane

2017-10-31

Abstract excerpt

Mammalian cell sphingolipids, primarily with C24 and C16 acyl chains, reside in the outer leaflet of the plasma membrane. Curiously, little is known how C24 sphingolipids impact cholesterol and membrane microdomains. Here, we generated giant unilamellar vesicles and live mammalian cells with C24 or C16 sphingomyelin exclusively in the outer leaflet and compared microdomain formation. In giant unilamellar vesicles,...

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Identifiers and source

Literature Corpus work
ed8892a3-5212-500c-a1ac-3426f0351d91
DOI
10.1101/212142
Open publication

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C24 sphingolipids play a surprising and central role in governing cholesterol and lateral organization of the live cell plasma membraneDOI 10.1101/212142
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