Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The AD3 locus of synaptotagmin-1 C2 domains modulates domain stability.

Biophysical journal - 3 Jun 2025

Dominguez Matthew J, Bui Anthony A, Villarreal Johanna, Snow Adam, Karmakar Souvic, Harsini Faraz M, Rock Patrick J, Rice Anne M, Fuson Kerry L, Sutton R Bryan

Abstract excerpt

Synaptotagmin-1 (syt1) functions as the Ca2+-dependent sensor that triggers the rapid and synchronous release of neurotransmitters from neurotransmitter-containing vesicles during neuronal exocytosis. The syt1 protein has two homologous tandem C2 domains that interact with phospholipids in a Ca2+-dependent manner. Despite the crucial role of syt1 in exocytosis, the precise interactions between Ca2+, syt1, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Calcium

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drosophila melanogaster

Share to Drosophila Proteins

Share to Molecular Dynamics Simulation

Share to Protein Stability

Share to Synaptotagmin I

Share to Thermodynamics

Source

Open in PubMed Open full text

Identifiers

PMID: 39578407
DOI: 10.1016/j.bpj.2024.11.009
PMCID: PMC12256881

Genes

C2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The AD3 locus of synaptotagmin-1 C2 domains modulates domain stability.PMID 39578407Read ↗

Disease-causing mutations in Synaptotagmin can act via dominant-negative, gain-of-function or haploinsufficient mechanismsSemantic proximity Read ↗

Delineation of the pathogenic presynaptic mechanisms of synaptotagmin-1 variantsSemantic proximity Read ↗

Synaptotagmin oligomerization is essential for calcium control of regulated exocytosis.Semantic proximity Read ↗

The C2A domain of synaptotagmin alters the kinetics of voltage-gated Ca2+ channels Ca(v)1.2 (Lc-type) and Ca(v)2.3 (R-type).Semantic proximity Read ↗

Regulation of spontaneous neurotransmission and homeostatic synaptic plasticity by synaptotagmin-1 disease variants at the SNARE primary interfaceSemantic proximity Read ↗

Adaptive functions correlate with evoked neurotransmitter release in SYT1-associated neurodevelopmental disorderSemantic proximity Read ↗

Genetic analysis of synaptotagmin C2 domain specificity in regulating spontaneous and evoked neurotransmitter release.Semantic proximity Read ↗

Skywalker-TBC1D24 has a lipid-binding pocket mutated in epilepsy and required for synaptic function.Semantic proximity Read ↗

Vesicle docking and fusion pore modulation by the neuronal calcium sensor Synaptotagmin-1.Semantic proximity Read ↗

Vesicle docking and fusion pore modulation by the neuronal calcium sensor Synaptotagmin-1Semantic proximity Read ↗

Functional and biochemical analysis of the C2 domains of synaptotagmin IV.Semantic proximity Read ↗

SYT1-associated neurodevelopmental disorder: a case seriesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.