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<p class="MDPI12title">The Allosteric Tug-of-War: Competitive Zinc and Dopamine Binding at the N-Terminal G14R Mutation Site of α-Synuclein

2026-01-06

Abstract excerpt

The G14R mutation in α-synuclein is associated with aggressive, early-onset Parkinson’s disease, yet its impact on the protein’s N-terminal regulatory domain remains poorly understood. As an intrinsically disordered protein, α-synuclein’s conformational landscape is highly sensitive to sequence perturbations and ligand interactions. This study investigates a hypothesized "allosteric tug-of-war" between pro-aggrega...

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Literature Corpus work: b3d6dc29-8628-56fb-aa72-4154a175216d
DOI: 10.20944/preprints202601.0362.v1

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<p class="MDPI12title">The Allosteric Tug-of-War: Competitive Zinc and Dopamine Binding at the N-Terminal G14R Mutation Site of α-SynucleinDOI 10.20944/preprints202601.0362.v1Read

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