Article

A molecular switch between mammalian MLL complexes dictates response to Menin-MLL inhibition

2021-10-22

Abstract excerpt

<h4>ABSTRACT</h4> The chromatin adaptor Menin interacts with oncogenic fusion proteins encoded by MLL1 -rearrangements ( MLL1 -r), and small molecules that disrupt these associations are currently in clinical trials for the treatment of leukemia. By integrating chromatin-focused and genome-wide CRISPR screens with genetic, pharmacological, and biochemical approaches in mouse and human systems, we discovered a m...

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Literature Corpus work: bed54f87-fa4a-540b-9bbf-e5b1a0084a52
DOI: 10.1101/2021.10.22.465184

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