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Integrating Natural and Engineered Genetic Variation to Decode Regulatory Influence on Blood Traits

2024-08-05

Abstract excerpt

Understanding the function of genetic variants associated with human traits and diseases remains a significant challenge. Here we combined analyses based on natural genetic variation and genetic engineering to dissect the function of 94 non-coding variants associated with haematological traits. We describe 22 genetic variants impacting haematological variation through gene expression. Further, through in-depth fun...

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Literature Corpus work
ed4e96aa-150b-5879-b2d7-c47fe2c70b9b
DOI
10.1101/2024.08.05.606572
Open publication

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Integrating Natural and Engineered Genetic Variation to Decode Regulatory Influence on Blood TraitsDOI 10.1101/2024.08.05.606572
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