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Article

DNA Methylation Alterations in Fractionally Irradiated Rats and Breast Cancer Patients Receiving Radiotherapy.

International journal of molecular sciences - 19 Dec 2022

Sallam Magy, Mysara Mohamed, Benotmane Mohammed Abderrafi, Tamarat Radia, Santos Susana Constantino Rosa, Crijns Anne P G, Spoor Daan, Van Nieuwerburgh Filip, Deforce Dieter, Baatout Sarah, Guns Pieter-Jan, Aerts An, Ramadan Raghda

Abstract excerpt

Radiation-Induced CardioVascular Disease (RICVD) is an important concern in thoracic radiotherapy with complex underlying pathophysiology. Recently, we proposed DNA methylation as a possible mechanism contributing to RICVD. The current study investigates DNA methylation in heart-irradiated rats and radiotherapy-treated breast cancer (BC) patients. Rats received fractionated whole heart X-irradiation (0, 0.92, 6.9...

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Identifiers

PMID: 36555856
DOI: 10.3390/ijms232416214
PMCID: PMC9783664

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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