Article

The ribosomal protein L22 binds the <i>MDM4</i> pre-mRNA and promotes exon skipping to activate p53 upon nucleolar stress

2023-12-29

Abstract excerpt

<h4>ABSTRACT</h4> The tumor suppressor p53, along with its antagonists MDM2 and MDM4, represents a central integrator of stress signaling. While DNA damage is the most widely explored trigger of a p53 response, stress arising from dysbalanced assembly of ribosomes in nucleoli is also linked to p53 induction. Deletions of the gene encoding the ribosomal protein L22 (RPL22; eL22) correlate with the presence of full...

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Literature Corpus work: ed3c7d65-45e3-5b79-9abd-c466f235f504
DOI: 10.1101/2023.12.29.573614

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