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Ribosomal Protein L11 Negatively Regulates Oncoprotein MDM2 and Mediates a p53-Dependent Ribosomal-Stress Checkpoint Pathway

12 Nov 2003

Abstract excerpt

The gene encoding p53 mediates a major tumor suppression pathway that is frequently altered in human cancers. p53 function is kept at a low level during normal cell growth and is activated in response to various cellular stresses. The MDM2 oncoprotein plays a key role in negatively regulating p53 activity by either direct repression of p53 transactivation activity in the nucleus or promotion of p53 degradation in...

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PMID: 14612427
DOI: 10.1128/mcb.23.23.8902-8912.2003

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Related research

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Ribosomal Protein L11 Negatively Regulates Oncoprotein MDM2 and Mediates a p53-Dependent Ribosomal-Stress Checkpoint PathwayPMID 14612427Read ↗

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Ribosomal stress induces L11- and p53-dependent apoptosis in mouse pluripotent stem cellsSemantic proximity Read ↗

Ribosomal Proteins RPL37, RPS15 and RPS20 Regulate the Mdm2-p53-MdmX NetworkSemantic proximity Read ↗

Ribosomal proteins as unrevealed caretakers for cellular stress and genomic instabilitySemantic proximity Read ↗

The ribosomal protein L22 binds the <i>MDM4</i> pre-mRNA and promotes exon skipping to activate p53 upon nucleolar stressSemantic proximity Read ↗

The RP-Mdm2-p53 Pathway and TumorigenesisSemantic proximity Read ↗

Ribosomal protein RPL11 haploinsufficiency causes anemia in mice via activation of the RP-MDM2-p53 pathway.Semantic proximity Read ↗

Cancer-associated mutations in the MDM2 zinc finger domain disrupt ribosomal protein interaction and attenuate MDM2-induced p53 degradation.Semantic proximity Read ↗

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