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Article

Ribosomal stress induces L11- and p53-dependent apoptosis in mouse pluripotent stem cells

1 Feb 2012

Abstract excerpt

Ribosome biogenesis is the most demanding energetic process in proliferating cells and it is emerging as a critical sensor of cellular homeostasis. Upon disturbance of ribosome biogenesis, specific free ribosomal proteins, most notably L11, bind and inhibit Mdm2, resulting in activation of the tumor suppressor p53. This pathway has been characterized in somatic and cancer cells, but its function in embryonic...

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PMID: 22262176
DOI: 10.4161/cc.11.3.19002

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